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Zetpil Calcium and Magnesium with K1 & D3 Suppository Nutrition

Price: $49.95

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Calcium & Magnesium
Vitamin D3 and Cofactors

30 Suppository Dosages

Pharmaceutical Grade

Zetpil™ Calcium and Magnesium with Vitamin D3 and Cofactors provides the RDA levels of elemental calcium that go directly into the cells and bloodstream. The most effective solution for individuals that suffer from poor or inadequate intestinal absorption
of calcium. Provides 100% absorption of nutraceuticals via suppository without
degradation in the stomach or liver as with oral supplements.

Both calcium and magnesium are essential to healthy and productive physiological well being.

The calcium and magnesium suppository provides the RDA levels of elemental calcium in the most bioactive forms that go directly into the cells. Magnesium deficiency has an effect on the absorption and release of calcium which is crucial to physical well being.

The Calcium and Magnesium suppository provides a person with the essential amounts of elemental calcium and is the most effective solution for individuals that suffer from poor or inadequate intestinal absorption of calcium.

Osteoporosis and low bone mass are currently estimated to be a major public health threat for almost 44 million U.S. women and men aged 50 and older, representing 55% of the people aged 50 and older in the United States.


·        This product is especially important for patients who have conditions in which nutrient malabsorption is an integral part of the disease process (i.e. celiac disease, Crohn’s Disease, Cystic Fibrosis, etcetera) or have undergone surgical malabsorption procedures including but not limited to: Roux en Y Gastric Bypass Surgery, Biliopancreatic Diversion, Duodenal Switch, Gastric Sleeve (VSG), Vertical Banded Gastroplasty (VBG) WLS-Bypass and Gastric Band and Mini Gastric Bypass Surgery.

·        Case studies have demonstrated this specially formulated suppository to be the only means of efficiently delivering therapeutically required dosages needed to meet the needs patients who suffer from poor absorption or malabsorption of Calcium and Vitamin D.


Osteoporosis can be described as a childhood deficiency disease that expresses itself in old age. However, osteoporosis is not, and should not, be considered part of the normal aging process. Osteoporosis is a metabolic bone disease that is characterized by low bone mass and deterioration of bone tissue leading bone fragility and increased risk of fracture. Simply put, thinning bones lead to fractures.

Although osteoporosis and osteopenia are primarily diagnosed by measuring bone mass, there are numerous other calcium deficiency signs and symptoms. These include: arthritis pain, joint pain, muscle cramps, spasms, twitches, nervousness, neuromuscular excitability, eczema, high blood pressure back pains (sciatica, disc problems), osteopenia, osteoporosis, muscle cramps, spasms, twitches, nervousness, neuromuscular excitability, osteofibrosis (enlargement of bones with scar tissue), panic attacks,  bell’s palsy, bone spurs, brittle fingernails, calcium deposits, cognitive impairment, delusions, depression, eczema, high blood pressure, hyperactivity, hypertension, insomnia, irritability, kidney stones, limb numbness and periodontal disease (osteoporosis of the facial and jaw bones).

Osteoporosis and Severe Low Calcium Levels have Become a Serious Problem for the Post Surgical Gastric Bypass Patients Populations.


An increase in long-term risk of osteoporosis and osteopenia have been well documented Slater[1] followed Roux en Y Gastric Bypass (RYGB) Biliopancreatic Diversion, Duodenal Switch (BPD/DS). Four years after the surgery, 63% of the patients were vitamin D deficient, 48% had low blood calcium levels.  Using more sophisticated urine tests[2] found that all of the post menopausal women in the study who had undergone RYGB surgery had evidence of secondary hyperparathyroidism, elevated bone resorption and patterns of bone loss.


Further, dietary (note oral) supplementation with vitamin D and 1200 mg of calcium daily did not change these measures indicating the need for a more effective means of supplementation.  In the same paper, a smaller study found every postsurgical person who had undergone RYGB surgery were found to have significant changes in total hip, trochanter, and total body bone mineral density as a result of increased bone resorption beginning as early a 3 months after having had the surgery.


Calcium and Vitamin D are Important!

Calcium is important for the maintaining healthy bones. Although 90% of the absorbed calcium is used in the formation of bone, calcium performs other important functions. Clinical trials have provided ample evidence that low calcium and low Vitamin D levels are conditions that increase the risk of many common chronic and life threatening diseases. In addition to bone disorders, calcium and Vitamin D deficits increase the risk many types of cancers (in particular colon, breast and prostate cancer), chronic inflammatory and autoimmune diseases (e.g. diabetes mellitus type 1, inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis), metabolic disorders (i.e. metabolic syndrome and high blood pressure) as well as peripheral vascular disease (e.g. narrowing of vessels that carry blood to the legs, arms, stomach or kidneys).

Low Vitamin D levels have been associated with associated with weight gain and obesity. Buffington et al. found that 62% of woman with weight problem had levels of D3 less than normal.[3]

Low calcium levels have also been shown to inhibit weight loss. Therefore, the  increased calcium intake of calcium in conjunction with a lower caloric diet has demonstrated increased weight loss and maintenance of lower weight levels.[4] [5] [6]

Why the Zetpil™ Calcium and Magnesium with Vitamin D and Cofactors Suppository makes Sense!

Calcium is one the difficult mineral nutrients to absorb. In adults, calcium is absorbed in the upper part of the small intestine (duodenum) with as little as 7-20% of ingested dietary elemental calcium ingested being absorbed. Additionally, there number key factors that are required for adequate oral calcium absorption include adequate amounts of protein, phosphorous, and vitamin D. That means that for many, the assumption that they are achieving adequate calcium intake from their diet or and/or an oral 1000 mgs calcium supplement, is often not true.

First, many formulations of supplemental calcium such as the calcium carbonate are very poorly absorbed. Second, although certain forms are better absorbed the amount of elemental calcium is so low as to the recommended dosage is inadequate. Calcium citrate is often touted as the standard in calcium products but it only contains 20% elemental calcium of which only a percentage of this calcium can be absorbed. For example, in post menopausal women the level of calcium absorption from dietary sources may drop to as low as 7 percent (Sourer, 1995). Additionally there are foods and combinations of foods that reduce the amount of the ingested calcium than can be absorbed. A partial list of factors that can reduce or inhibit calcium absorption include: high or excessive intakes of oxalates and phytates, found in foods such as spinach, whole grains and unleavened whole wheat products; consumption of alcohol, coffee, caffeinated beverages, energy drinks, sugar; use of medications such as antiseizure medications, benzodiazepines (e.g. Xanax, Librium, Valium, Ativan, etcetera) glucocorticoids medications (e.g. hydrocortisone, Prednisone, dexamethasone, etcetera),  thyroid medications, diuretics (i.e., water pills), tetracycline; aluminum containing antacids (i.e., Tums); stress and a lack of exercise all negatively effect calcium levels and contribute to poor absorption of calcium from foods and oral supplements. Therefore, when the numerous factors that can inhibit calcium absorption are considered, a person with low dietary intake and poor intestinal absorption might be required to take as many as 20 (twenty) 500mg  calcium citrate tablets or capsules per day to obtain adequate calcium. 


Why Zetpil™ Calcium and Magnesium with Vitamin D and Cofactors might be the a Safe Alternative for the Treatment of Osteoporosis and Osteopenia as opposed to the early use Bisphosphonates (Fosamax, Actonel, Zometa and Boniva).


Many healthcare professionals believe that the best way to treat or prevent osteoporosis and/or osteopenia is by the dietary intake of foods containing calcium and/or the use of  oral calcium supplements and the many cofactors needed for its absorption and utilization. However, the inability to of many individuals to ingest and absorb adequate calcium levels prompted the pharmaceutical industry to develop a new class of medications for osteoporosis/osteopenia called bisphosphonates. Aggressive marketing has influenced many in the medical community to tout bisphosphonates (Fosamax, Actonel, Zometa and Boniva) as the best preventative approach and/or the best treatment approach for osteoporosis or osteopenia.


But there are many healthcare professionals that have serious reservations. Researchers in Spain, Canada, and Australia recently warned that many younger postmenopausal women are taking drugs whose risks may outweigh the benefit of a safer approach.


First, bisphosphonates works by inhibiting bone resorption. Unfortunately that’s not as good as it may sound. Bone formation requires a certain amount of bone resorption. Therefore if resorption (i.e. bone loss) is delayed, then so is new bone formation. In fact the development of osteonecrosis (bone decay) with the use of Fosamax may be based on this effect.


Second, these medications still require adequate intake of calcium and vitamin D.  In Wolters & Kulwer’s Facts & Comparisons 2008 (the pharmacist’s reference book on prescription medications) under Dietary Intake, the prescribing information clearly states that “the patient should receive supplemental calcium and vitamin D if the dietary intake is inadequate”, therefore even if you chose to take these medications you still need to absorb adequate calcium and vitamin D in order for these medications to be effective. In fact a recent research study by the pharmaceutical company Merck found that about 8 million women had lower bone mass (osteopenia) and fully one third of these women were taking bisphosphonates/osteoporosis drugs.

Third, it is well known in the medical community that these medications have a number of side effects. Some of the most common side effects of these medications include bone, muscle, or joint pain; constipation; diarrhea; dizziness; feeling bloated or full; flu-like symptoms at the start of treatment; gas; headache; mild stomach pain; nausea; taste changes; vomiting. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry, or bloody stools; chest pain; coughing or vomiting blood; difficult or painful swallowing; mouth sores; new, worsening, or severe heartburn; red, swollen, blistered, or peeling skin; severe bone, muscle, or joint pain; severe or persistent sore throat or stomach pain; swelling of the hands, legs, or joints; swelling or pain in your jaw. The most severe side effect associated with the use of the bisphosphonates Fosamax and Fosamax D has been linked to the painful and often disfiguring and irreversible condition-osteonecrosis (bone decay) of the jaw (also referred to as ONJ, Dead Jaw or Bis-Phossy Jaw). More recent studies show that use of Fosamax and Fosamax Plus D can also lead to osteonecrosis of the hip and osteonecrosis of the shoulder, as well as of the knee. It appears Merck, the manufacturer of Fosamax, knew about the risk of osteonecrosis of the jaw, but failed to take steps to properly warn patients, doctors and dentists. Remarkably Fosamax and Fosamax Plus D had sales of $2.8 billion for 2007 and is still one of the most prescribed medications for osteoporosis/osteopenia!

The Zetpil™ Calcium and Magnesium with Vitamin D and Cofactors Suppository: Safe & Effective

Over the past year, we have been tracking our patients who had been diagnosed with osteoporosis/osteopenia. The patients who committed to using the suppositories on a daily basis were able to re-establish normal bone density levels in as little as 1 year with no side effects and very little inconvenience. Also, the patients who took the suppositories stated that a number of other problems associated with calcium deficiency (arthritis pain, joint pain, muscle cramps, spasms, twitches, nervousness, eczema, high blood pressure back pains, brittle fingernails, insomnia, irritability, kidney stones, more regular bowel movements and better and more complete evacuation) also appeared to resolved themselves during the course of treatment with the suppositories. The patients stated that taking 2 suppositories before bed was both easy and comfortable. In fact when asked if they would go back to taking oral calcium supplements, the universally stated that they now preferred to take Zetpil™ Calcium and Magnesium PLUS with Vitamin D instead of swallowing up to 12 to 20 capsules of 500 mg calcium citrate EVERY DAY.

Supplement Facts

Serving Size: 1 Suppository
Servings Per Container: 30

Amount Per Serving

Elemental Calcium

160 mg

Elemental Magnesium

40 mg

Vitamin D3

1000 iu

Vitamin K1

60 mcg

Each Zetpil™ Calcium and Magnesium with Vitamin D and Cofactors suppository contains a proprietary blend of the following: highly bioavailable forms of Calcium yielding 160 mg Elemental Calcium; 200 mg of highly bioavailable forms of Magnesium yielding 40 mg of elemental Magnesium; Vitamin D3 1000 iu.; Vitamin K1 60 mcg. Suppository Base The base is a proprietary combination of plant and fruit butters, medium chain triglycerides, natural phospholipids, lecithin, methyl cellulose, vegetable starches, guar gum and xanthan gum.

Recommended use: 2-3 per day or as directed by your health care professional. Note* Two (2) packages (60 suppositories) of the Zetpil™ Calcium and Magnesium with Vitamin D and Cofactors supplies a 30 day course of calcium replacement therapy, and it has been observed
that restoration of calcium levels in individuals experiencing intestinal malabsorption requires long-term supplementation. However, serum calcium levels should be assessed every 6 months.


It is highly recommended you attempt to clear your bowels prior to inserting a suppository to avoid premature evacuation after the suppository has been inserted. To facilitate insertion it is recommended you moisten suppository with warm water. Zetpil™ suppositories require a minimum of 20-30 minutes in the rectum to ensure adequate absorption of the ingredients. If inserted while lying on one’s side, consider remaining in the supine position for 10 minutes following insertion.

CONTRAINDICATIONS: This product is contraindicated in individuals with a known hypersensitivity phospholipids, sesame seeds or any of the ingredients should avoid taking this product.



  • Keep this product out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
  • As with any nutrient, if you are breast-feeding, seek the advice of a health care provider before using this product.

Note: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore
we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion
Avoid excessive heat 40°C (104°F).
Store in a cool place 8° to 15°C (46° to 59°F) or refrigerate.

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

Please note that current FDA safety regulations indicate that the suppositories cannot
 be returned and are therefore non-refundable

Manufactured exclusively for Zetpil USA, LLC, West Palm Beach, Florida

Copyright ©2008 Zetpil™ USA, LLC All rights reserved

1) Slater GH, Ren CJ, Seigel N, et al. Serum fat-soluble vitamin deficiency and abnormal calcium metabolism after malabsorptive bariatric surgery. J Gastrointest Surg 2004; 8:48-55

2) Goode LR, Brolin RE, Chowdry HA, Shapes SA. Bone and gastric bypass surgery: effects of dietary calcium and D. Obes Res 2004;12:40-7

2)Goode LR, Brolin RE, Chowdry HA, Shapes SA. Bone and gastric bypass surgery: effects of dietary calcium and D. Obes Res 2004;12:40-7

3) Buffington CK, Walker B, Cowan GS, et al. Vitamin D Deficiency in the morbidly obese. Obes Surg 2005;15:330-5

4) International Journal of Obesity & Related Metabolic Disorders, Sep 16, 2003 / Hopkins PN, Polukoff GI. Risk of valvular heart disease associated with use of fenfluramine. BMC Cardiovasc  Disord. 2003 Jun 11;3(1):5.

5) Zemel MB , Shi H, Greer B, Dirienzo D, Zemel PC. Regulation of adiposity by dietary calcium. FASEB J. 2000 Jun;14(9):1132-8.

6) Heaney RP, Davies KM, Barger-Lux MJ. Calcium and weight: clinical studies. J Am Coll Nutr. 2002 Apr;21(2):152S-155S.Increasing calcium intake could reduce the risk of overweight substantially, perhaps by as much as 70 percent. (1 kilogram is equal to 2.2 pounds.)





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