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· This product is especially important for patients who have conditions in which nutrient malabsorption or chronic nutrient deficiencies are an integral part of the disease process (i.e. Celiac Disease, Crohn’s Disease, Cystic Fibrosis, Fibromyalgia, Restless Leg Syndrome, etcetera) or have undergone surgical malabsorption procedures including but not limited to: Roux en Y Gastric Bypass Surgery (RYGB), Biliopancreatic Diversion,
· Case studies have demonstrated this innovative suppository to be a SAFE, COMFORTABLE and CONSISTENTLY EFFECTIVE means to deliver iron supplementation to treat Iron Deficiency Anemia (IDA). This suppository was first developed for the post surgical Gastric Bypass Surgery patient to conveniently and efficiently deliver a therapeutically effective dosage of iron and the necessary cofactors in a once a day dosage.
The prevalence of iron deficiency is well documented. Government statistics indicate that 3.4 million Americans are anemic, However, National Anemia Action Council, Inc. (NAAC), an organization of anemia experts http://www.anemia.org/, believes the number is far greater. Millions more suffer from subclinically low iron or low ferritin levels (the stored
A serious problem is the development of Iron Deficiency Anemia (IDA) as well as multiple nutrient deficiencies in the post surgical Gastric Bypass Surgery patient population. The most current studies on patients that have undergone Roux en Y Gastric Bypass Surgery (RYGB), Biliopancreatic Diversion, Duodenal Switch (BPD/DS), Gastric Sleeve (VSG), Vertical Banded Gastroplasty (VBG) WLS-Bypass and Gastric Band and Mini Gastric Bypass Surgery have demonstrated that iron deficiency is very common (almost predictable) after this surgery with anemia occurring in 50%-74% up three years after the surgery.
Skoubis G, Sakellarapoulos G, Pouggouras K., Comparison of nutritional deficiencies after Roux-en-Y gastric bypass. Obes Surg 2002;12:551-8
The Zetpil™ Suppository with Vitamin, Mineral, Iron and Amino Acid
Cofactors is a SAFE, EFFECTIVE and WELL TOLERATED solution for the treatment
Our research team has developed the Zetpil™ Suppository with Vitamin, Mineral, Iron and Amino Acid Cofactors to be the most efficient and effective Iron
WHY A RECTAL SUPPOSITORY?
Many individuals cannot tolerate oral iron supplements, experiencing number of
Problems Associated With Intramuscular or Intravenous Iron Replacement Therapy
The use of intramuscular or intravenous therapy is reserved for individuals that are severely anemic. The use Intramuscular injections, although still done, has fallen into disfavor by many in the medical community because intramuscular iron injections
Intravenous iron therapy also poses risks and potential side effects and is generally reserved for patients whose are iron deficient with a hemoglobulin levels at or below 8.0 g/dl. In the case of chronic malabsorption, individuals with chronic Iron deficiency Anemia (IDA) who receive intravenous iron dextrin therapy are often unable maintain their levels with follow-up daily doses of oral iron supplements and therefore require repeated intravenous iron treatments as they develop iron deficient anemia over and over again. Prior the development of the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral
Another complication that occurs in Individuals who are required to undergo recurrent intravenous iron therapy to treat this “anemia rollercoaster” is the collapse of the veins
Another common dilemma occurs in individuals who are clearly anemic and significantly symptomatic but because the levels are not low enough (Hemoglobulin at/or below 8 g/dl) to warrant exposing the individual to the risks and potential side effects of intramuscular
· futile attempts to raise the iron levels and treat the iron deficiency with higher and higher dosages of oral supplements (triggering many of the side effects associated with higher oral iron supplements);
· see healthcare practitioners, unaware of the complexity of the issue, believe these individuals can raise their level if they just eat a healthier diet or take a different form of oral iron;
· see healthcare practitioners who question their commitment or compliance with
· see practitioners who are frustrated and chose to ignore the condition
· see practitioners who just refer these patients out;
· just accept the fact that there is nothing that can be done.
Non-laxative rectal suppositories have been used to deliver medications since the 1840s. The general principle is that the suppository, used after a bowel movement, is inserted in its tapered form blunt side first and then dissolves inside the rectum delivering the compounds inside the suppository form into the body.
Exploring and building on this fundamental concept, our research team developed the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors logically deducing that it would make more sense to avoid the damaged or compromised structures involved in oral iron absorption by the delivery of the iron and the essential nutrient co-factors nutrients directly into the body via this alternative route. Although this common sense seems simple enough, it has taken our research team taken 5 years and countless hours of tireless research to develop an all natural suppository that was safe, effective, comfortable, hypoallergenic and essentially side effect free as the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors. This innovative suppository delivers the highest quality vitamins, minerals and amino acids
The Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors has been shown to be effective in as little as 6-8 weeks. However, it is important to keep in mind that iron deficiencies cannot be corrected overnight and depending on the extent of the deficiency it may take up to 6 months of iron supplementation to replenish
Each Zetpil™ Multi-Vitamin, Multi-Mineral with Iron & Amino Acid Co-Factors contains the following ingredients: Iron (a proprietary blend of 3 highly bioavailable iron compounds) yielding 19 mg of elemental iron; Vitamin A 2500 iu; Vitamin D3 (as cholecalciferol) 5000 ius; Ascorbyl Palmitate 45 mg; Vitamin B1/
TTFD 5 mg; B2/Riboflavin-5-Phosphate 6mg; Vitamin B3/Niacinamide12mg; Pantothenic Acid 12 mg Vitamin B6/Pyrdoxal-5-Phosphate 6 mg; Biotin 600mcg; Folinic Acid 2.5 mg; Vitamin B12 (as a proprietary blend of methylcobalamin and cobamamide) 800mcg; Calcium 140mg; Zinc 20 mg; Manganese 20mg; Selenium 2.5mg; Copper 500 mcg; Chromium 250mcg; Vanadium 500mcg; and Molybdenum 100 mcg; Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives. Recommended use: 1 to 3 per day (if deficient) preferably before bedtime, or as directed by your health care professional.
If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation. To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).
· Although safe for children, this product should be kept out of the reach of children.
· Do not use if the suppositories are open or damaged.
· As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
This product contains an extract from soybeans. This product is contraindicated in individuals with a known hypersensitivity to phospholipids, sesame seed oils or any of the ingredients and should avoid taking this product.
Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.
Disclaimer: These statements have not been evaluated by the FDA This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a substitute for sound medical advice.
Farmaceutische Zetpillen BV Ltd – Essentiële Nutriënten, Nutraceutische en Kruiden Afdeling, St. Johns, Antigua
Distributed by Zetpil Nutritionals USA, Lake Worth, Florida 33467 (561) 682-1101
CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity phospholipids, sesame seeds or any of the ingredients. Hemochromatosis and hemosiderosis are contraindications to iron therapy.
General: Do not exceed recommended dose. The type of anemia and the underlying cause or causes should be determined before starting therapy with Ferrosorb. Since the anemia may be a result of a systemic disturbance, such as recurrent blood loss, the underlying cause or causes should be addressed and corrected.
Pediatric Use: Safety and effectiveness in pediatric patients have not been clearly established. Therefore seek the advice of a healthcare professional before using.
ADVERSE REACTIONS: Adverse reactions with both oral and parenteral iron therapy may include constipation, diarrhea, nausea, vomiting, dark stools and abdominal pain. Allergic sensitization has been reported following both oral and parenteral administration of folic acid. However, significantly less allergic sensitivity and constipation, diarrhea, nausea, vomiting, dark stools and abdominal pain have been demonstrated in extensive clinical usage with rectal administration of these specialized forms of iron.
OVERDOSAGE: The clinical course of acute iron overdosage can be variable. Initial symptoms
Note: Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F).
Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.
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