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Zetpil MultiVitamin and MultiMineral with Iron Suppositories, 30 Count

Price: $89.95

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ZETPIL-RX

Multivitamin and Mineral with Iron

Especially formulated with Cofactors for Optimal Iron Absorption

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30 Dosages

Pharmaceutical Grade

 STORE IN REFRIGERATOR

 This product can often be stored at room temperature from 21°C /70°F to 28°C /82°F.  However, to allow for optimal ease of use, it is best to store in a cool place (15°C /59°F to 22°C /72°F),  in the refrigerator or freezer prior to use.  This is especially important when this product is used as a suppository (See Directions). If the materials in the shell liquefy/melt during shipping, remove the shells from the packaging, shake/agitate the strips and then place in the freezer until the product in the shell hardens (10-15 minutes).  Although the re-hardened material in the shell may be slightly misshapen, the softening, shaking and cooling of the suppository in no way alters the effectiveness of the active ingredients or overall product delivery into the body. 

Iron deficiency and associated nutrient deficient anemias afflicts almost 2 billion patients worldwide making it the most prevalent nutrient deficiency in the world.

 

·        This product is especially important for patients who have conditions in which nutrient malabsorption or chronic nutrient deficiencies are an integral part of the disease process (i.e. Celiac Disease, Crohn’s Disease, Cystic Fibrosis, Fibromyalgia, Restless Leg Syndrome, etcetera) or have undergone surgical malabsorption procedures including but not limited to: Roux en Y Gastric Bypass Surgery (RYGB), Biliopancreatic Diversion,
Duodenal Switch (BPD/DS), Gastric Sleeve (VSG), Vertical Banded Gastroplasty (VBG) WLS-Bypass and Gastric Band and Mini Gastric Bypass Surgery.

·        Case studies have demonstrated this innovative suppository to be a SAFE, COMFORTABLE and CONSISTENTLY EFFECTIVE means to deliver iron supplementation to treat Iron Deficiency Anemia (IDA). This suppository was first developed for the post surgical Gastric Bypass Surgery patient to conveniently and efficiently deliver a therapeutically effective dosage of iron and the necessary cofactors in a once a day dosage.

 

The prevalence of iron deficiency is well documented. Government statistics indicate that 3.4 million Americans are anemic, However, National Anemia Action Council, Inc. (NAAC), an organization of anemia experts http://www.anemia.org/, believes the number is far greater. Millions more suffer from subclinically low iron or low ferritin levels (the stored
form of iron). Based on statistics and other scientific findings regarding the prevalence of anemia among patients with chronic diseases,
National Anemia Action Council, Inc. (NAAC) has identified anemia as an under-diagnosed public health concern that requires concerted attention and action (see Understanding Iron Deficient Anemia)

 

A serious problem is the development of Iron Deficiency Anemia (IDA) as well as multiple nutrient deficiencies in the post surgical Gastric Bypass Surgery patient population. The most current studies on patients that have undergone Roux en Y Gastric Bypass Surgery (RYGB), Biliopancreatic Diversion, Duodenal Switch (BPD/DS), Gastric Sleeve (VSG), Vertical Banded Gastroplasty (VBG) WLS-Bypass and Gastric Band and Mini Gastric Bypass Surgery have demonstrated that iron deficiency is very common (almost predictable) after this surgery with anemia occurring in 50%-74% up three years after the surgery.


Brolin RE, LaMerca LB, Henler HA, Cody RP. Malabsorptive gastric bypass in patients with super obesity. J Gastrointest Surg 2002;6:195-203

Skoubis G, Sakellarapoulos G, Pouggouras K., Comparison of nutritional deficiencies after Roux-en-Y gastric bypass. Obes Surg 2002;12:551-8

 

The Zetpil Suppository with Vitamin, Mineral, Iron and Amino Acid 

Cofactors is a SAFE, EFFECTIVE and WELL TOLERATED solution for the treatment
of
Iron Deficiency Anemia (IDA), Subclinical Iron Deficiencies, Pernicious Anemia, and Megablastic Anemia.

Our research team has developed the Zetpil™ Suppository with Vitamin, Mineral, Iron and Amino Acid Cofactors to be the most efficient and effective Iron
supplement currently available on the market.

WHY A RECTAL SUPPOSITORY?

Many individuals cannot tolerate oral iron supplements, experiencing number of
adverse reactions which force many individual to stop taking iron. Also, poor absorption
of oral supplements is a frustratingly ineffective failure in many medical conditions where individuals suffer from chronic malabsorption. This is especially true for individuals
that have undergone Gastric Bypass Surgery.
Iron deficiency is a major problem in these individuals with up to 74% developing Iron deficiency Anemia (IDA) and low ferritin (low stored iron levels) in spite of these individuals regularly taking oral iron supplements.

Problems Associated With Intramuscular or Intravenous Iron Replacement Therapy

The use of intramuscular or intravenous therapy is reserved for individuals that are severely anemic. The use Intramuscular injections, although still done, has fallen into disfavor by many in the medical community because intramuscular iron injections
requires a relatively high degree of skill and care to administer, are usually quite painful, patients often experience permanent scaring over the site of the healed injections and
are no safer than intravenous therapy,

Intravenous iron therapy also poses risks and potential side effects and is generally reserved for patients whose are iron deficient with a hemoglobulin levels at or below 8.0 g/dl. In the case of chronic malabsorption, individuals with chronic Iron deficiency Anemia (IDA) who receive intravenous iron dextrin therapy are often unable maintain their levels with follow-up daily doses of oral iron supplements and therefore require repeated intravenous iron treatments as they develop iron deficient anemia over and over again.  Prior the development of the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral
and Amino Acid Cofactors,
an individual with recurrent iron deficient anemia had no option but to suffer while they progressively became sicker and until their levels again
were low enough to justify treatment with intravenous iron replacement treatments. This slow and progressive drop in iron levels and hemoglobulin  often takes months, all the while, the iron deficient individual suffers  from the debilitating symptoms of iron deficient anemia. As you might imagine, this combination of chronic illness and repetitive therapy takes both a physical and emotional toll.

Another complication that occurs in Individuals who are required to undergo recurrent intravenous iron therapy to treat this “anemia rollercoaster” is the collapse of the veins
used for the intravenous therapy. Often these patients will require the use of either a Peripherally Inserted Catheter (PIC) or a Central Venous Line (CVL) with all the
discomfort, inconvenience and complications associated with those procedures. Again
this is a significant problem with patients who have undergone Gastric Bypass Surgery procedures as well as other patients with medical conditions with chronic malabsorption that require recurrent iron infusions. 

Another common dilemma occurs in individuals who are clearly anemic and significantly symptomatic but because the levels are not low enough (Hemoglobulin at/or below 8 g/dl) to warrant exposing the individual to the risks and potential side effects of intramuscular
or intravenous iron replacement therapy. However, because these individuals do not respond adequately to oral iron replacement therapy, these individuals are trapped in the painfully symptomatic and debilitating world of permanent iron deficiency anemia. For
those who suffer from medical conditions such as Celiac Disease, Crohn’s Disease, Cystic Fibrosis, Fibromyalgia, Restless Leg Syndrome, etcetera where nutrient malabsorption is a constant problem, this can be physically and emotionally draining.
This is especially true for the postsurgical Gastric Bypass Surgery patients who experience chronic subclinical iron deficiency and Iron Deficient Anemia (IDA) along with
a number of other clinical or subclinical deficiencies of the needed nutrient co-factors that can make iron replacement virtually impossible. Until the development of the Zetpil™
Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Ferrosorb with
Vitamin, Mineral and Amino Acid Cofactors suppository,
an individual’s options with this condition were quite limited:

·         futile attempts to raise the iron levels and treat the iron deficiency with higher and higher dosages of oral supplements (triggering many of the side effects associated with higher oral iron supplements);

·         see healthcare practitioners, unaware of the complexity of the issue, believe these individuals can raise their level if they just eat a healthier diet or take a different form of oral iron;

·         see healthcare practitioners who question their commitment or compliance with
the recommended ineffective therapy;   

·         see practitioners who are frustrated and chose to ignore the condition

·         see practitioners who just refer these patients out;                                                                                                                        

·         just accept the fact that there is nothing that can be done.


The Solution

Non-laxative rectal suppositories have been used to deliver medications since the 1840s. The general principle is that the suppository, used after a bowel movement, is inserted in its tapered form blunt side first and then dissolves inside the rectum delivering the compounds inside the suppository form into the body.

Exploring and building on this fundamental concept, our research team developed the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors logically deducing that it would make more sense to avoid the damaged or compromised structures involved in oral iron absorption by the delivery of the iron and the essential nutrient co-factors nutrients directly into the body via this alternative route. Although this common sense seems simple enough, it has taken our research team taken 5 years and countless hours of tireless research to develop an all natural suppository that was safe, effective, comfortable, hypoallergenic and essentially side effect free as the Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors. This innovative suppository delivers the highest quality vitamins, minerals and amino acids
in a specialized combination of highly absorbable forms of iron,
the most bioactive forms
of the B vitamins (e.g., specialized of form of Folic Acid, the specialized forms of B12:
pure methylcobalamin and adenylcobalamin), specialized mineral micronutrients and the specific amino acids needed in the conversion of elemental iron to resolve Iron Deficiency Anemia (IDA) as well as anemias due to a deficiency of other essential nutrients.

The Zetpil™ Ferrosorb Suppository with Vitamin, Mineral and Amino Acid Cofactors has been shown to be effective in as little as 6-8 weeks. However, it is important to keep in mind that iron deficiencies cannot be corrected overnight and depending on the extent of the deficiency it may take up to 6 months of iron supplementation to replenish
the iron that your body needs to function properly.


Each Zetpil™ Multi-Vitamin, Multi-Mineral with Iron & Amino Acid Co-Factors contains the following ingredients: Iron (a proprietary blend of 3 highly bioavailable iron compounds) yielding 19 mg of elemental iron; Vitamin A 2500 iu; Vitamin D3 (as cholecalciferol) 5000 ius; Ascorbyl Palmitate 45 mg; Vitamin B1/

TTFD 5 mg; B2/Riboflavin-5-Phosphate 6mg; Vitamin B3/Niacinamide12mg; Pantothenic Acid 12 mg Vitamin B6/Pyrdoxal-5-Phosphate 6 mg; Biotin 600mcg; Folinic Acid 2.5 mg; Vitamin B12 (as a proprietary blend of methylcobalamin and cobamamide) 800mcg; Calcium 140mg; Zinc 20 mg; Manganese 20mg; Selenium  2.5mg; Copper 500 mcg; Chromium 250mcg; Vanadium 500mcg; and Molybdenum 100 mcg; Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives. Recommended use: 1 to 3 per day (if deficient) preferably before bedtime, or as directed by your health care professional.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

WARNINGS

·          Although safe for children, this product should be kept out of the reach of children.

·          Do not use if the suppositories are open or damaged.

·          As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

This product contains an extract from soybeans. This product is contraindicated in individuals with a known hypersensitivity to phospholipids, sesame seed oils or any of the ingredients and should avoid taking this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.                           

OM078MVI                                                                                                                                                                

Farmaceutische Zetpillen BV Ltd – Essentiële Nutriënten, Nutraceutische en Kruiden Afdeling, St. Johns, Antigua

Distributed by Zetpil Nutritionals USA, Lake Worth, Florida 33467 (561) 682-1101

CONTRAINDICATIONS: This product is contraindicated in patients with a known hypersensitivity phospholipids, sesame seeds or any of the ingredients. Hemochromatosis and hemosiderosis are contraindications to iron therapy.

 

WARNINGS

  • Folic acid alone is improper therapy in the treatment of pernicious anemia and other megaloblastic anemias where Vitamin B12 is deficient.
  • Keep this product out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.
  • As with any nutrient, if you are breast-feeding, seek the advice of a health care provider before using this product.1


    PRECAUTIONS      
                                                                                                                                                                                    

General: Do not exceed recommended dose. The type of anemia and the underlying cause or causes should be determined before starting therapy with Ferrosorb. Since the anemia may be a result of a systemic disturbance, such as recurrent blood loss, the underlying cause or causes should be addressed and corrected.                                                                                                                                                         
Folic Acid: 1 mg of folic acid as folinic acid is contained in this product. Although, folic acid in
doses above 1.0 mg daily may obscure B12 dependent pernicious anemia in that hematologic remission can occur while neurological manifestations remain progressive, this product contains vitamin B12 in its two most bioactive forms. Therefore, the potential for folic acid to mask the symptoms of pernicious anemia is to be minimal.                                                                                                                                                                    

Pediatric Use:  Safety and effectiveness in pediatric patients have not been clearly established. Therefore seek the advice of a healthcare professional before using.                                                                                                         
Geriatric Use: Clinical studies on this product have not been performed in sufficient numbers of subjects aged 65 and over to determine whether elderly subjects respond differently from younger subjects. Therefore, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range (1 suppository per day). Higher dosages should reflect decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.

 

ADVERSE REACTIONS: Adverse reactions with both oral and parenteral iron therapy may include constipation, diarrhea, nausea, vomiting, dark stools and abdominal pain. Allergic sensitization has been reported following both oral and parenteral administration of folic acid. However, significantly less allergic sensitivity and constipation, diarrhea, nausea, vomiting, dark stools and abdominal pain have been demonstrated in extensive clinical usage with rectal administration of these specialized forms of iron.

                                                    

OVERDOSAGE: The clinical course of acute iron overdosage can be variable. Initial symptoms
may include abdominal pain, nausea, vomiting, diarrhea, tarry stools, melena, hematemesis, hypotension, tachycardia, metabolic acidosis, hyperglycemia, dehydration, drowsiness, pallor, cyanosis, lassitude, seizures, shock and coma.        
                                                                                       

Note:  Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F).   

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

Please note that current FDA safety regulations indicate that the suppositories cannot
be returned and are therefore non-refundable

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