Product Type

Shopping Cart

-Your cart is empty.-

Zetpil Reduced Glutathione Suppository 450 Pure Pharmaceutical Grade Antioxidant Nutrient Vitamin

Price: $199.95

Add to Cart


Reduced Glutathione 450





This product can often be stored at room temperature from 21°C /70°F to 28°C /82°F.  However, to allow for optimal ease of use, it is best to store in a cool place (15°C /59°F to 22°C /72°F),  in the refrigerator or freezer prior to use.  This is especially important when this product is used as a suppository (See Directions). If the materials in the shell liquefy/melt during shipping, remove the shells from the packaging, shake/agitate the strips and then place in the freezer until the product in the shell hardens (10-15 minutes).  Although the re-hardened material in the shell may be slightly misshapen, the softening, shaking and cooling of the suppository in no way alters the effectiveness of the active ingredients or overall product delivery into the body.                                                                                                                                        

Note*** Reduced Glutathione (rGSH) is the bioactive form of glutathione and the only effective form (see discussion). Prior to the development of the rectal suppository the only other effective forms of Reduced Glutathione (rGSH) occurred as intramuscular injections, nebulized (inhaled mist) and intravenous Infusions.

Zetpil™ Reduced Glutathione with TMG & Orotates suppository is simply put, an amazing product. The bioactive reduced form of Glutathione is considered to be the most powerful, most versatile and most important of the body’s self generated antioxidants that is found in almost all living cells. It is also considered
to be one of the most powerful anticancer agents manufactured by the body. Reduced Glutathione (rGSH) works as a detoxification, or chelating, agent which works to remove heavy metals and other common toxins that our bodies are exposed to on a regular basis. It is also used to aid in treatment of liver disease, ulcers and neurological conditions, as well as to assist in overall immune function. The
Zetpil™ Reduced Glutathione with TMG & Orotates suppository when combine with bound orotic acid and trimethylglycine aid the body in neutralizing
free radicals and prevent their formation, while protecting valuable proteins.

Among Reduced Glutathione’s (rGSH) many important properties are:  

  • Is found in almost all living cells. The liver, spleen, kidneys, pancreas, and the lens and cornea, have the highest concentrations in the body.
  • It is a MOST POWERFUL ANTIOXIDANT and thus neutralizes free radicals and prevents their formation.
  • Reduced Glutathione is involved in maintaining normal brain function.
  • Diabetes mellitus: Especially in ketosis as DM patients will generally excrete increased amounts of sulfur containing amino acids.
  • Immune enhancement: 1-3 g per day. This is especially effective against clostridium in the GI. It helps prevent translocation.
  • Effective adjunct for Psoriasis.
  • Liver disease including cirrhosis and fatty liver disease caused by alcohol.
  • Parkinson's disease, Alzheimer’s Disease, ALS (Lou Gherig’s disease), Multiple Sclerosis and other neurologic conditions including Autism/Pervasive Developmental Delay and Chronic Kidney Failure.
  • Ulcers intestinal or stomach: In patients with stomach ulcers low levels of GSH have been found.
  • Aspirin or phenacetin overdose (useful for rheumatoid arthritis patients or chronic pain sufferers on 8 or more aspirin/day).
  • Hematological conditions: myelofibrosis, acute leukemia, chronic myelocytic leukemia, lymphoma, polycythemia vera.
  • Alcoholism.
  • Before radiation therapy.
  • Cataracts.
  • Important role in immune function via white blood cell production and is one of the most potent
    anti-viral agents known.
  • It is one of the strongest anti-cancer agents manufactured by the body.
  • It is used by the liver to detoxify toxins including formaldehyde, acetaminophen, benzpyrene
    and many other compounds.
  • It is an antioxidant necessary for the protection of proteins; is involved in nucleic acid synthesis and plays a role in DNA repair, It maintains the cellular redox potential
  • Reduced Glutathione levels decrease with age. It is involved in cellular differentiation and
    slows the aging process.
  • Protects the integrity of red blood cells.

Therapeutically, Reduced Glutathione (rGSH) is used for: 

    -Heavy metal toxicity including mercury, lead, arsenic and cadmium:
    -Common toxins that Reduced Glutathione may help protect against car exhaust,  
     cigarette smoke, aspirin and alcohol (Marz, p. 78, 1997) 
    -Pesticide and industrial chemical exposure
    -Bacterial toxins (Clostridia difficile)
    -Pharmaceuticals that affect the liver) (Marz, p. 79, 1997)   

Although many have touted the benefits of this product, it was sold in an oral form to those who required the potential benefits of elevation the intracellular levels of Glutathione with reduced glutathione. However, what was not revealed by those who chose to sell reduced glutathione or glutathione (the totally ineffective form)
was that ORAL FORMS OF REDUCED GLUTATHIONE OR GLUTATHIONE SUPPLEMENTS DO NOT RAISE TISSUE LEVELS OF BIOACTIVE FORM OF CELLULAR GLUTATHIONE AND ARE INEFFECTIVE. Although some might argue that the orals might be effective, the effective therapeutic dosage levels of the reduced glutathione (the only effective form) required costly dosages of 3000 mgs with a very small possibility of being effective. The reason the oral form of reduced glutathione is ineffective is because when ingested orally reduced glutathione (rGSH) undergoes hydrolysis by intestinal and hepatic (liver) alpha glutamyltransferase
that that renders the reduced glutathione ineffective  Hagen TM, Wierzbicka GT, Sillau AH, et al. Bioavailability of dietary glutathione: effect on plasma concentrations. Am J Physiol 1990;259:G524-529.

It must be emphasized that Glutathione (not reduced) has no clinical use and although some would have you believe that the reduced form and the unreduced form are one in the same, the misrepresentation of non-reduced Glutathione as an effective form appears to be either the result of a lack of scientific knowledge or a purposeful attempt to deceive a patient population looking for help.   

However, the development of the Zetpil™ Reduced Glutathione with TMG & Orotates suppository in combination with Zetpil™ ‘s proprietary base, is a scientifically sound mode of delivery and is clearly offers an alternative means to raise the reduced glutathione levels to effectively act as an antioxidant  other than by intramuscular injections, nebulized (nasal mist) or by intravenous administration of reduced glutathione. Unfortunately these forms are either uncomfortable (daily intramuscular injections) or costly intravenous therapy.

Therefore when one considers that the Zetpil™ Reduced Glutathione with TMG & Orotates suppository is effective means of delivering the body’s most powerful antioxidant in a cost effective form that can be taken indefinitely, this breakthrough form of delivering Reduced Glutathione raises the bar in effective antioxidant therapy for the patient population who desire an effective, affordable and potent solution at a fraction of the
cost of current effective means of delivering this important product.

Dosages per Package 30                                                                             

Each Zetpil™ Reduced Glutathione 450 contains the following: Reduced Glutathione 450 mgs and a therapeutically effective proprietary blend of NAC, Taurine and reduced Glutathione 12X. Base: The base is a proprietary combination of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharides derivatives, polysaccharides and cycloamylose derivatives.

Recommended use: 1 to 3 suppositories per day or as directed by your health care professional.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).

Note: Zetpil™ Reduced Glutathione Plus can be taken at any time during the day. It can also be taken immediately before bed time in order to facilitate the body’s repair processes that occur during the sleep state.


·    Although safe for children, this product should be kept out of the reach of children.

·    Do not use if the suppositories are open or damaged.

·    As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

This product contains an extract from soybeans. This product is contraindicated in individuals with a known hypersensitivity to phospholipids, sesame seed oils or any of the ingredients and should avoid taking this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

The addition of a homeopathic dilution of 12X has been added to enhance the efficacy of this product. Therefore, these products may also be considered to be homeopathic in nature. Accordingly, these products comply with FDA regulations regarding the formulation and production of homeopathic products. 

Disclaimer: These statements have not been evaluated by the FDA This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff), nor is this product  a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice. 


Farmaceutische Zetpillen BV Ltd – Essentiële Nutriënten, Nutraceutische en Kruiden Afdeling, St. Johns, Antigua

Distributed by Zetpil Nutritionals USA, Lake Worth, Florida 33467


It is highly recommended you attempt to clear your bowels prior to inserting a suppository to avoid premature evacuation after the suppository has been inserted. To facilitate insertion it is recommended you moisten suppository with warm water. Zetpil™ suppositories require a minimum of 20-30 minutes in the rectum to ensure adequate absorption of the ingredients. If inserted while lying on one’s side, consider remaining in the supine position for 10 minutes following insertion.

It is RECOMMENDED that you always attempt to move your bowels prior to inserting the suppository even if you do not feel the need to avoid discharging of the suppository before the suppository can be totally absorbed. Note that after a short time of use you will become cognizant
of when to take the suppositories. It is recommended that the suppository be retained for at least 30 (thirty) minutes to insure adequate absorption of the nutrients, neutraceutical and herbal ingredients contained herein.

CONTRAINDICATIONS: This product is contraindicated in individuals with a known
hypersensitivity phospholipids, sesame seeds or any of the ingredients
should avoid taking
this product. Hemochromatosis and hemosiderosis are contraindications to iron therapy.



In rare case, minor side effects may include rectal pressure and urge to defecate. If you experience any such effects, please refer to Frequently Asked Questions or How to Take a Rectal Suppository and adjust dosage accordingly. This suppository contains Vitamin C. However, when taking N-acetyl –cysteine it is recommended that and individual maintain adequate levels of Vitamin C.

Note:  Storing this product at room temperature will not alter the effectiveness or potency. However a firm suppository is necessary for a comfortable and easy insertion. Therefore we recommend that this product be stored in the refrigerator to maintain firmness. If the suppository does become soft, place the suppository in the refrigerator to achieve the firmness needed for comfortable insertion Avoid excessive heat 40°C (104°F). Store in a cool place 15° to 25°C (59°F to 78°F) or refrigerate.

Disclaimer: The statements above have not been evaluated by the FDA. The nutritional suggestions and research provided are for informational purposes only and are not intended to diagnose, treat, cure or prevent disease and should not be used as a substitute for sound medical advice. Please see your health care professional in all matters pertaining to your physical health.

Please note that current FDA safety regulations indicate that the suppositories cannot
be returned and are therefore non-refundable.

I do not accept returns

Destination: United States

CarrierMethodShipping CostPer additional Item
USPSPriority Mail®$8.00

Destination: Worldwide

Calculate cost
Payment Method


Instructions to Buyer

Included in the handling cost (Domestic)
Included in the handling cost (International)
Online Store Powered by Vendio | Privacy Policy